Drug testing would be much more simpler, faster, and more cost effective - if we simply focused on Pharmacokinetics. If we did this, we would not need a small group of people or a larger number of patients and so much time and money etc. With a pill for example all a lab has to do is watch what happens as soon as it enters the mouth and is met with enzymes, then on down to the stomach, intestines, liver and kidneys where other natural organic dynamics "destroy the pill". Destroy is not the word they use - it's a naughty word, even thought it is the correct word. The word science uses instead is the pill gets "metabolized" (aka, destroyed).
The molecules that are assembled to make a pill be come undone, not just the pill as a whole, but the individual molecules. Some molecules might escape the gauntlet of natural body defenses (the body is adroitly designed to defend against foreign, alien matter, especially toxic components which are the bulk of a pills ingredients) - but that amount is also on its way out via pee and poop. Certain drugs, like uppers and downers can make their way to the nervous system and have effect, but most drugs are not to be stimulants and depressants.
The largess of pharma drugs aim to go into the body, remain intact and positively impact the body - but not one drug can make this claim, can speak to this kind of success.
And what is important to remember is that as the body battles to sustain homeostasis, it takes a toll. The battle we engage when the body fights drugs and other foreign elements can be a fierce one, most times we win, some times we lose the battle, but each time, each battle, the body is a little more scarred.
The body has the great capacity to heal, to replenish cells, but a continued onslaught of drug intake will take its toll and organs will begin to tap out and fail - especially the liver and kidneys which are the first lines of defense for things that get into the blood.
Finding truly effective ways to deliver a drug into the body has forever been the bane of the pharmaceutical business. And still, in the year 2025 we have not at all succeeded in this area - and drugs still get approved. We feel testing for 2 or 4 years is adequate but many times the deleterious effects of drugs is not sudden but gradual. And yes, for many, the negative impact is immediate. Oliver
Hi Olivier, thanks for your comment. If we focused on only pharmacokinetics as you suggest, we will only see what the body does to the drug (how it metabolizes it) and lose all the information about what the drug does to the body - also called pharmacodynamics. Pharmacodynamics is essential in ensuring an effective treatment because it will eventually tell us if the drug is taking it out its desired effect. There is no point in testing a drug if we only look at pharmacokinetics because then we don't even see if the drug is actually doing what we designed for it to do.
In terms of the metabolism of drugs, it's true that the body will degrade foreign molecules that enter your body, including even the food you eat. But pharmacologists keep that in mind and usually design their active ingredient in such a way that it becomes one of the final metabolites after the body has received and broken down the drug.
Finally, I just want to note that a drug usually goes through 10-15 years of testing on humans before it is approved (not 2-4 years as you mentioned). And even after it is approved the FDA always monitors for new adverse side effects and can still pull the drug off the market if it is seen to have a negative effect.
- Pharmacokinetics is the study of how a living organism interacts with a drug
- Pharmacodynamics is the study of how a drug affects the body.
What I was saying in my first reply was that co-kinetics renders co-dynamics useless or pointless in that the pill is destroyed , beyond repair, by numerous natural body dynamics (defenses). So, there thus is no realized desired effect. If I am designing a car and in the factory putting it through it's paces to see how it holds up in the real world, and it crumbles to bits and pieces after the first crash test, then we know that care failed, it can't carry and deliver any kind of cargo to and or from.
If I take a sledge hammer to my watch or cell phone and shatter both to bits and pieces, these items will not be functioning at all.
There appears to be 2 science camps, legitimate lab folk - who are not communicating with each other, not sharing notes if you will. One camp is testing drug delivery methods for pills, the statin pill say, and realizing that time and again, this pill is demolished (metabolized) by various natural dynamics, starting with the enzymes in the mouth. These scientists suggest that perhaps 8 or 9 percent of the pill might still be "available" once the fully intact pill runs through the gauntlet of body dynamics (from mouth to bile). Even though this camp knows that the bile is the last stop before the toilet.
But again, if only 8 percent of my car, cell phone or watch is still available after being destroyed, what real good can my car do? Nothing, that car, if it even looks like a car after 92 percent has been destroyed, is useless. So too, my watch, cell phone and that pill.
The other camp of scientists, all still good decent hardworking educated people, they feel there is nothing to see here, that these drugs work, and pay no attention to the demolished car, the scraps, the shrapnel that remains after meeting up with the harsh dynamics of the human body. This camp of scientists swear by the efficacy of these utterly damaged pills. In the case of statins, they swear they are effective in lowering your cholesterol - even as those who study statin delivery are screaming, no, the body reject statin pills at every pass and reduces this pill to nothing and escort the meaningless remains out the body via pee and poop.
Here is a study done by lab folk the speaks to the issue of statin pill delivery and it highlights new, recent methods of getting the cholesterol lowering drug into the body - because they know the old pill has no chance. But even these new methods are suspect because again, the body is designed to reject, repulse all foreign matter.
Here the one camp insists statins work because we see lower levels in the patient after a while - never considering (it seems) that the patient stopped doing what they did prior to the cardiac event (drinking, smoking, being lazy, eating a poor diet etc. and reversed lifestyle and diet habits after being in the hospital...
And the other camp also knows that pill had no way of lowering cholesterol because it was destroyed and escorted out of the body.
And remember, this destroying of drugs by the body takes a great toll on the body, especially the liver and kidneys. That people are put on a lifetime of statins and or blood thinners is tragic and a bad job by the medical science community.
PS It is my hope, my efforts, to get some of the new generation of science minds to connect these real dots and not just look the other way, or stick to status quo, or have business as usual. Some young science student needs to step out of line, raise their hand and say to the class, we have been doing this all wrong, we keep making drugs that invariably fail, due to the body rejecting them, as the drugs do damage in the process. It is my hope. It is my hope. Business as usual is killing so many people
Drug testing would be much more simpler, faster, and more cost effective - if we simply focused on Pharmacokinetics. If we did this, we would not need a small group of people or a larger number of patients and so much time and money etc. With a pill for example all a lab has to do is watch what happens as soon as it enters the mouth and is met with enzymes, then on down to the stomach, intestines, liver and kidneys where other natural organic dynamics "destroy the pill". Destroy is not the word they use - it's a naughty word, even thought it is the correct word. The word science uses instead is the pill gets "metabolized" (aka, destroyed).
The molecules that are assembled to make a pill be come undone, not just the pill as a whole, but the individual molecules. Some molecules might escape the gauntlet of natural body defenses (the body is adroitly designed to defend against foreign, alien matter, especially toxic components which are the bulk of a pills ingredients) - but that amount is also on its way out via pee and poop. Certain drugs, like uppers and downers can make their way to the nervous system and have effect, but most drugs are not to be stimulants and depressants.
The largess of pharma drugs aim to go into the body, remain intact and positively impact the body - but not one drug can make this claim, can speak to this kind of success.
And what is important to remember is that as the body battles to sustain homeostasis, it takes a toll. The battle we engage when the body fights drugs and other foreign elements can be a fierce one, most times we win, some times we lose the battle, but each time, each battle, the body is a little more scarred.
The body has the great capacity to heal, to replenish cells, but a continued onslaught of drug intake will take its toll and organs will begin to tap out and fail - especially the liver and kidneys which are the first lines of defense for things that get into the blood.
Finding truly effective ways to deliver a drug into the body has forever been the bane of the pharmaceutical business. And still, in the year 2025 we have not at all succeeded in this area - and drugs still get approved. We feel testing for 2 or 4 years is adequate but many times the deleterious effects of drugs is not sudden but gradual. And yes, for many, the negative impact is immediate. Oliver
Hi Olivier, thanks for your comment. If we focused on only pharmacokinetics as you suggest, we will only see what the body does to the drug (how it metabolizes it) and lose all the information about what the drug does to the body - also called pharmacodynamics. Pharmacodynamics is essential in ensuring an effective treatment because it will eventually tell us if the drug is taking it out its desired effect. There is no point in testing a drug if we only look at pharmacokinetics because then we don't even see if the drug is actually doing what we designed for it to do.
In terms of the metabolism of drugs, it's true that the body will degrade foreign molecules that enter your body, including even the food you eat. But pharmacologists keep that in mind and usually design their active ingredient in such a way that it becomes one of the final metabolites after the body has received and broken down the drug.
Finally, I just want to note that a drug usually goes through 10-15 years of testing on humans before it is approved (not 2-4 years as you mentioned). And even after it is approved the FDA always monitors for new adverse side effects and can still pull the drug off the market if it is seen to have a negative effect.
- Pharmacokinetics is the study of how a living organism interacts with a drug
- Pharmacodynamics is the study of how a drug affects the body.
What I was saying in my first reply was that co-kinetics renders co-dynamics useless or pointless in that the pill is destroyed , beyond repair, by numerous natural body dynamics (defenses). So, there thus is no realized desired effect. If I am designing a car and in the factory putting it through it's paces to see how it holds up in the real world, and it crumbles to bits and pieces after the first crash test, then we know that care failed, it can't carry and deliver any kind of cargo to and or from.
If I take a sledge hammer to my watch or cell phone and shatter both to bits and pieces, these items will not be functioning at all.
There appears to be 2 science camps, legitimate lab folk - who are not communicating with each other, not sharing notes if you will. One camp is testing drug delivery methods for pills, the statin pill say, and realizing that time and again, this pill is demolished (metabolized) by various natural dynamics, starting with the enzymes in the mouth. These scientists suggest that perhaps 8 or 9 percent of the pill might still be "available" once the fully intact pill runs through the gauntlet of body dynamics (from mouth to bile). Even though this camp knows that the bile is the last stop before the toilet.
But again, if only 8 percent of my car, cell phone or watch is still available after being destroyed, what real good can my car do? Nothing, that car, if it even looks like a car after 92 percent has been destroyed, is useless. So too, my watch, cell phone and that pill.
The other camp of scientists, all still good decent hardworking educated people, they feel there is nothing to see here, that these drugs work, and pay no attention to the demolished car, the scraps, the shrapnel that remains after meeting up with the harsh dynamics of the human body. This camp of scientists swear by the efficacy of these utterly damaged pills. In the case of statins, they swear they are effective in lowering your cholesterol - even as those who study statin delivery are screaming, no, the body reject statin pills at every pass and reduces this pill to nothing and escort the meaningless remains out the body via pee and poop.
Here is a study done by lab folk the speaks to the issue of statin pill delivery and it highlights new, recent methods of getting the cholesterol lowering drug into the body - because they know the old pill has no chance. But even these new methods are suspect because again, the body is designed to reject, repulse all foreign matter.
Here the one camp insists statins work because we see lower levels in the patient after a while - never considering (it seems) that the patient stopped doing what they did prior to the cardiac event (drinking, smoking, being lazy, eating a poor diet etc. and reversed lifestyle and diet habits after being in the hospital...
And the other camp also knows that pill had no way of lowering cholesterol because it was destroyed and escorted out of the body.
And remember, this destroying of drugs by the body takes a great toll on the body, especially the liver and kidneys. That people are put on a lifetime of statins and or blood thinners is tragic and a bad job by the medical science community.
See Link: https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1139-8#:~:text=In%20conclusion%2C%20due%20to%20several,have%20been%20investigated%20for%20this
Here is a short video that shows how drugs are escorted out of the body: https://www.youtube.com/watch?v=795CmRHVRUs
PS It is my hope, my efforts, to get some of the new generation of science minds to connect these real dots and not just look the other way, or stick to status quo, or have business as usual. Some young science student needs to step out of line, raise their hand and say to the class, we have been doing this all wrong, we keep making drugs that invariably fail, due to the body rejecting them, as the drugs do damage in the process. It is my hope. It is my hope. Business as usual is killing so many people
Sincerely, Oliver